Educational, research-use-only content. This article summarizes published scientific literature for informational purposes only and is not medical advice. The compounds discussed are supplied strictly for in-vitro laboratory research and are not approved for human or veterinary use.
What is NAD+?
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It carries electrons in reduction-oxidation reactions and serves as a cosubstrate for enzymes such as the sirtuins and PARPs. Cellular NAD+ levels are reported to change with aging (Verdin, 2015).
Aging and metabolism research
A widely cited review discusses how modulating NAD+ production or use can influence health span and life span in model organisms, and frames NAD+ precursors as a research opportunity for aging and neurodegeneration (Verdin, 2015). Cardiac-focused work reviews how NAD+ pools decline with aging and how precursor supplementation shows benefit across preclinical cardiovascular models (Abdellatif et al., 2021).
The limits of the current evidence
- Much of the supporting data is preclinical; human clinical outcomes remain under active study.
- NAD+ is supplied here as a research compound; it is not an approved drug and has not been evaluated by the U.S. Food and Drug Administration for treatment.
References
According to PubMed:
- Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015. doi:10.1126/science.aac4854
- Abdellatif M, Sedej S, Kroemer G. NAD+ Metabolism in Cardiac Health, Aging, and Disease. Circulation. 2021. doi:10.1161/CIRCULATIONAHA.121.056589
