Educational, research-use-only content. This article summarizes published scientific literature for informational purposes only and is not medical advice. The compounds discussed are supplied strictly for in-vitro laboratory research and are not approved for human or veterinary use.

What is SLU-PP-332?

SLU-PP-332 is a synthetic agonist of the estrogen-related receptors (ERRs), with the highest potency at ERRα. ERRs are orphan nuclear receptors that play a role in skeletal-muscle exercise capacity, and SLU-PP-332 is studied as a so-called “exercise mimetic” research compound (Billon et al., 2023).

What the research examined

In a skeletal-muscle cell line, SLU-PP-332 increased mitochondrial function and cellular respiration. In mice, it increased oxidative (type IIa) muscle fibers and enhanced exercise endurance, and it induced an ERRα-specific acute aerobic-exercise gene program; ERRα activation was shown to be necessary for the endurance effect (Billon et al., 2023).

The limits of the current evidence

  • The evidence is from cell and mouse studies; SLU-PP-332 is a research compound, not an approved medicine, and human data are lacking.
  • This material is for laboratory research use only.

References

According to PubMed:

  1. Billon C, et al. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023. doi:10.1021/acschembio.2c00720
Disclaimer: This content is educational only and reflects published research. It is not medical advice and makes no claim regarding the diagnosis, treatment, cure, or prevention of any disease. Products referenced are for in-vitro laboratory research use only (RUO); they are not for human or veterinary use. Where a compound has regulatory approval or is in clinical trials, that does not apply to the research material sold here.

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